are some of the benefits of earlier detection/intervention of disease? Question 1 options: Lower cost, complexity, and side effects gher survival, probability of care Increased

are some of the benefits of earlier detection/intervention of disease? Question 1 options: Lower cost, complexity, and side effects gher survival, probability of care Increased health span and quality of life Prevent & cure diseases Match the terms with their correct definitions: Question 2 options: The chemical changes to DNA and histone proteins, like DNA methylation and histone modification All the genetic material of an organism The set of proteins expressed under specific conditions The complete set of small-molecules present within an organism, cell, or tissue The set of all RNA transcripts (coding and non-coding) in a specified cell population Genome Epigenome Transcriptome Proteome Metabolome Signatures of metabolites can be used to predict disease status and trajectory of disease. Question 3 options: The largest modifiable risk factor that leads to disease are dietary factors. Question 4 options: is the “the quantified self,” according to Dr. Floyd Chilton in his Nutrigenomics lecture? Question 5 options: A major trend encouraging the movement towards personalized nutrition Quantifying personal characteristics to track and improve health An ideal for personalized medicine, but not really achievable due to the complexity of individual biology Quantifying ourselves each day, through various means of data collection According to Dr. Floyd Chilton’s Nutrigenomics lecture, which populations consistently have higher mortality rates between ages 1-64 compared to white individuals? Question 6 options: spanic American Indian African American Asian Which nutrient(s) from lecture did Dr. Chilton use to explain an example of the “Anatomy of Potentially Harmful Gene-Diet Interactions?” Question 7 options: Vitamin D Omega-3’s and 6’s Vitamin K Magnesium Metabolic markers (metabotype) can us begin to predict, diagnose, and possibly prevent disease earlier. Question 8 options: Which are the common methods of measuring metabolites using metabolomic and lipidomic techniques? Question 9 options: NMR Mass Spectrometry GC-FID CE Metabolites reflect only genetic, but not environmental influences. Question 10 options: Rank the current validity and utility of gene tests on the market, in order from MOST valid (1) to LEAST valid (4). Finally, list the EMERGING technologies as (5). Question 11 options: Hereditary cancers, Dx sequencing, PGx Polygenic risk scores, microbiome, ID Pharmacogenomics, 23andMe health tests 3rd party genetic interpretation services Wellness – diet, nutrition, exercise Week 1 PlayPosit – Sarah Lavelle & Ch 1 in Nutrigenomics Focusing on single nutrients to promote health (and NOT dietary patterns) is the best way to approach nutritional regimens & care. Question 12 options: The primary pathways of food intake regulation are: Question 13 options: Body water mass regulation Homeostatic regulation Energy expenditure sensing Hedonic sensations Inflammation & neuron injury can influence the CNS’s regulation of food intake. Question 14 options: The ______ is the first organ to receive absorbed nutrients. _______ primarily serves as energy storage, but is also an endocrine organ. ______ are the primary mode of body movements, which require glucose and fats. The ______ s regulate energy balance for the whole body. Question 15 options: liver, adipose tissue, skeletal muscles, brain adipose tissue, skeletal muscle, liver, brain brain, skeletal muscle, adipose tissue, liver adipose tissue, liver, skeletal muscle, brain Vitamins and minerals are calorie-containing nutrients. Question 16 options: Which is the major energy storage source in the human body? Question 17 options: Adipocytes Glycogen Branched chain amino acids Lipoproteins Obesity can increase the risk of which of the following conditions or problems? Question 18 options: Insulin Resistance & Type 2 Diabetes Polycystic Ovarian Disease (PCOD) Cardiovascular Disease (CVD) Obstructive Sleep Apnea (OSA) Psychosocial Problems 1/3 of cancer deaths are due to high BMI, low fruit & vegetable intake, lacking physical activity, and tobacco and alcohol use. Question 19 options: Increase in number and size of white adipocytes decreases the risk of obesity and associated diseases.

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